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Unopened semaglutide should remain refrigerated at 36F to 46F

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Semaglutide demonstrated a 20% MACE reduction in the SELECT trial

By contrast, tesamorelin's N-terminal trans-2-hexenoic acid modification addresses a different problem: GHRH has a short half-life in vivo due to dipeptidyl peptidase IV cleavage at the Tyr1-Ala2 bond